Because cancer treatment hasn’t materially changed in decades. Until now.
Metabolic Oncology
More Than Medicine. A New Path Forward.
Decades of research has slowly been building toward a fourth branch of oncology: metabolic oncology. While the current three branches of oncology attempt to surgically remove or kill cancer cells by methods specific to each cancer type, metabolic oncology broadly targets all cancer types by altering the tumor microenvironment and perturbing energy production pathways uniquely overexpressed and necessary for survival of cancer cells. In this way, metabolic oncology aims to 1) prepare or condition the patient to respond to traditional and targeted chemotherapeutic methods with fewer side effects and better outcomes and 2) treat cancer directly in the absence of safe and effective traditional oncologic therapies.
Surgical oncology
(removes tumors)
Radiotherapy
(directly targets tumors with ionizing radiation)
Medical oncology
(systemic therapies that target cancer cells but often adversely affect normal cells)
The Science of Metabolic Oncology:
Starving Cancer of the Fuel it Needs to Survive
All cancer types rely on glucose and glutamine as energy sources to survive. We are focused on exploiting that weakness to drive innovation in cancer therapy.
Hear Maggie's Story
From Diagnosis to Determination – A Journey Fueled by Science.
Our Sponsored Studies
In our sponsored ongoing projects and published experimental and clinical studies, dietary and/or drug interventions that reduce glucose and glutamine metabolism slowed cancer growth and improved outcomes. These studies demonstrate the promise of metabolic therapeutic interventions in cancer treatment.
Ongoing Projects
Preclinical studies are underway and a clinical study is being planned to further evaluate and optimize the benefit of adjuvant metabolic therapies in the treatment of metastatic cancer and glioblastoma multiforme.
Publications from Funded Research
We have supported experimental and clinical-case studies conducted by Dr. Thomas Seyfried and colleagues that strongly support metabolic therapies as important in the treatment and management of glioblastoma multiforme, a brain tumor resistant to conventional cancer therapies.
This is more than research. It is a chance to positively and profoundly impact the lives of cancer patients.
Metabolic Cancer Therapy:
Key Elements
There is rapidly growing preclinical and clinical evidence demonstrating the benefits of a ketogenic diet and repurposed safe and inexpensive drugs, vitamins, and supplements in metabolic cancer therapy. Treatments that work with the body not against it.
What Happens When We Remove Cancer’s Favorite Fuel?
In our studies, cutting off sugar and other key nutrients slowed down cancer growth.
Patients lived longer when treated with this new method alongside other therapies.
Mukherjee, P., Augur, Z.M., Li, M. et al. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol 2, 200 (2019)
Mukherjee, P., Augur, Z.M., Li, M. et al. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol 2, 200 (2019)
Bringing New Purpose to Trusted Medicines.
We are studying ways to improve the effectiveness of existing medications.
Our current work focuses on a medicine called Mebendazole, already used safely for other conditions. We believe it may offer new hope for brain cancer patients.
Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma:
Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma?
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma:
Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer:
Management of Glioblastoma Multiforme in a patient treated With Ketogenic Metabolic therapy and Modified standard of Care: a 24-Month Follow-Up:
